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What is the threshold plasma bicarbonate level that indicates higher bicarbonate concentration in dialysate is needed?

  1. 20 mEq/L

  2. 22 mEq/L

  3. 24 mEq/L

  4. 26 mEq/L

The correct answer is: 22 mEq/L

The optimal threshold plasma bicarbonate level indicating the need for a higher bicarbonate concentration in dialysate is 22 mEq/L. A bicarbonate level at or below this threshold suggests that the patient may be experiencing metabolic acidosis or insufficient correction of acidosis during dialysis. In patients with end-stage renal disease, maintaining proper acid-base balance is critical, as their kidneys can no longer adequately excrete acid or regenerate bicarbonate. When blood bicarbonate levels drop to around 22 mEq/L or lower, it becomes important to adjust the dialysate formulation to enhance bicarbonate delivery during treatment. This adjustment helps to effectively manage the patient’s acidosis and improve their overall metabolic status.